[ITK] ITK 4.5.1 daemons registration horrendously slow

[Armstrong, Hirotatsu]

Hello forum,

I am trying to deformably register 2 CT datasets (512x512x88) using the daemons algorithm, and it is taking much longer than I would expect.  I am using the symmetric daemons method, with 25 iterations and sd of 2.5, and it takes 35-45 minutes using 8 cpu cores (4 physical, 4 virtual).  From my understanding in the literature, daemons algorithms should be fast taking only a few minutes at most.  I have attached my code and was looking for any guidance on if I am doing something dumb/inefficient, or if the ITK implementation is known to be inefficient, or if I am just wrong in how much time I expect the registration should take.  I also attached my CMakeCache.txt file from my ITK build, according to that I have a proper release build (not debug), but maybe there is something else I should look for in terms of efficiency (special optimizations that should be turned on but are not).  Thank you very much.

James Armstrong, Ph.D.
PostDoctoral Fellow, Physics
Department of Radiation Oncology
University of Colorado School of Medicine
1665 Aurora Ct, MS F706
Aurora, CO 80045
720-848-0257

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