[vtkusers] VTK CISG Registration Toolkit 2.0
Thomas.Hartkens
thomas at hartkens.de
Sun Sep 15 14:11:40 EDT 2002
Computational Imaging Science Group
Prof. D.J. Hawkes and Dr. D.L.G. Hill
Guy's Hopital, King's College London
http://www-ipg.umds.ac.uk/cisg
present the new version of the
*******************************************************************
VTK CISG Registration Toolkit
version 2.0
for medical single- and multimodal 3D images
tested on Linux, Solaris, and Windows
http://www.image-registration.com
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written by T. Hartkens based on code by D. Rueckert and J. Schnabel
The new version includes the following new features:
- a completely re-written graphical user interface
- support of both 2D and 3D visualisation
- improved registration algorithm
- an graphical interface to detect anatomical landmarks in 3D
images supported by an 3D differential operator
- an approach to simplify 3D deformation fields
- many bug-fixes
Many of the new features can be seen in screenshots on our web-pages.
This software package provides two voxel-based image registration
algorithms on the basis of Normalised Mutual Information (NMI) which are
incorporated in a user-friendly command-line and graphical interface
including a visualisation tool for 3D image pairs in order to analyse
registration results. This software is implemented using the free and
widely-used visualisation software VTK version 4.0 by Kitware
(Visualization Toolkit; http://www.kitware.com) a powerful visualisation
pipeline for interactive image display. VTK4.0 needs to be
installed before the VTK CISG Registration Toolkit can be used.
We have shown that voxel-based image registration using Normalised
Mutual Information (NMI) can register single- and multi-modal 3D images
accurately without any user interaction using either rigid body or affine
transformations [1][2][3]. Our algorithm has been independently
validated as part of the Vanderbilt University RREP project [4].
Our group has also proposed a non-rigid registration algorithm based on
NMI [5], and has demonstrated these algorithms on a range of medical
applications such as serial MR images of the brain [6], breast [5],
cardiac and liver. We have recently proposed a validation strategy for
non-rigid registration algorithms and have used our non-rigid algorithm
as an example [7]. We have also shown how NMI based registration can
be used to provide a 3D calibration of MR and CT scanners [8] and US
scanners [9].
We would appreciate it if you would reference relevant papers from the
above list if you use the software and publish the results.
With this software we present a publicly available open-source
package that incorporates these algorithms in a user-friendly command-line
and graphical interface including a visualisation tool for 3D image
pairs in order to analyse registration results. Beside the pure usage
of registration algorithms, the software can be easily adjusted to
specific enviroments (e.g. including other image file formats) and can
be modified for specific applications. We would be delighted to recieve
from you any modifications that you make to the software plus any comments
you have about its usability and any publications that result from your
use of the software.
The version 2.0 of the VTK CISG Registration Toolkit can be now downloaded
for free on
http://www.image-registration.com
The VTK CISG Registration Toolkit is free software; you can redistribute
it and/or modify it under the terms of the GNU General Public License
as published by the Free Software Foundation; either version 2 of the
License, or (at your option) any later version.
This program is distributed in the hope that it will be useful,
but WITHOUT ANY WARRANTY; without even the implied warranty of
MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the
GNU General Public License for more details.
Best wishes,
Thomas Hartkens
References:
(1) Studholme C, Hill DLG, Hawkes DJ. 'Automated 3D registration
of MR and PET brain images by multi-resolution optimisation
of voxel similarity measures.' Medical Physics 24: 25-35 1997
(2) Studholme C, Hill DLG, Hawkes DJ, 'Automated 3D registration
of MR and CT images of the head.' Medical Image
Analysis 1(2): 163-175 1996
(3) Studholme C, Hill DLG, Hawkes DJ (1999) 'An overlap invariant
entropy measure of 3D medical image alignment'. Pattern
Recognition 32, 71-86.
(4) J. West et al. 'Comparison and evaluation of retrospective
intermodality brain image registration techniques',
JCAT, vol. 21, No 4., pp 554-566, 1997
(5) Rueckert D, Sonoda LI, Hayes C, Hill DLG, Leach MO, Hawkes DJ.
'Non-rigid Registration using Free-Form Deformations:
Application to Breast MR Images' IEEE Transactions on
Medical Imaging, Vol. 18, NO. 8: 712-721, August 1999
(6) Holden M, Hill DLG, Denton ERE, Jarosz JM, Cox TCS, Goody J,
Rohlfing T, Hawkes DJ. Voxel similarity measures for 3D serial
MR image registration IEEE trans Med. Imag. 19(2):94-102 2000
(7) JA Schnabel et al., Validation of non-rigid registration using Finite
Element Methods.
Information Processing in Medical Imaging (IPMI'01), LNCS 2082:344-357,
Springer
Verlag, 2001
(8) D.L.G. Hill, C.R. Maurer, C. Studholme, J.M. Fitzpatrick and D.J.
Hawkes, 'Correcting scaling
errors in tomographic images using a nine degree of freedom registration
algorithm',
JCAT, vol 22, pp 317-323, 1998
(9) J.M. Blackall, D. Rueckert, C.R. Maurer, G.P. Penny, D.L.G. Hill, D.J.
Hawkes, 'An Image
Registration Approach to Automated Calibration for Freehand 3D
Ultrasound',
MICCAI2000, S.L. Delp et al. (Eds.), LNCS 1935:462-471, Springer-Verlag,
2000
(10) T. Hartkens, D. Rueckert, J.A. Schnabel, D.J. Hawkes, D.L.G. Hill,
'VTK CISG Registration Toolkit: An open source software package for
affine and non-rigid registration of single- and multimodal 3D images.',
BVM2002, Leipzig, Springer-Verlag, March 2002,
http://www.bvm-workshop.org/
(11) T. Hartkens, D.L.G. Hill, A. D. Castellano-Smith, D.J. Hawkes,
C.R. Maurer, Jr., A. J. Martin, W.A. Hall, H. Liu, C.L. Truwit,
'Measurement and analysis of brain deformation during neurosurgery',
submitted 2002 to IEEE Transactions on Medical Imaging (TMI)
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Thomas Hartkens
Division of Radiological Sciences and Medical Engineering
Guy's, King's and St. Thomas' School of Medicine
Guy's Hospital, London SE1 9RT
tel: +44 20 7955 2721 fax: +44 20 7955 4532
mobile: +44 7967 323595
email: thomas.hartkens at kcl.ac.uk , thomas at hartkens.de
web: http://www-ipg.umds.ac.uk/t.hartkens
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Thomas Hartkens
Division of Radiological Sciences and Medical Engineering
Guy's, King's and St. Thomas' School of Medicine
Guy's Hospital, London SE1 9RT
tel: +44 20 7955 2721 fax: +44 20 7955 4532
mobile: +44 7967 323595
email: thomas.hartkens at kcl.ac.uk , thomas at hartkens.de
web: http://www-ipg.umds.ac.uk/t.hartkens
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