[Insight-users] vessel enhancing diffusion filter (release 200)

Oleksandr Dzyubak adzyubak at gmail.com
Wed Jun 18 11:12:59 EDT 2008


Hi Luis,

Of course, I meant to thank all the authors/developers. Thanks.

1) Well, number 6 comes from the Hessian matrix since it is symmetric.
I meant are there any other arrays should be held/allocated in memory or
lets put it that way, is it necessary to keep the  whole arrays  
permanently?

OK. I agree with you that since I run out of resources, some workarounds 
could be
a) process ROI
and/or
b) sacrifice an accuracy (is that so?) and use float or even short int.

3) Following your advice a wrote a simple code snippet
to test  memory allocation and the results are below.
 
********Begin Test
dzyubak at debian: /Memory$ ./a.out
How much memory (in MB) would you like to allocate?
2900
You are able to allocate: 2900 MB memory chunk
dzyubak at debian: /Memory$ ./a.out 2990
How much memory (in MB) would you like to allocate?
2990
Error: memory could not be allocated
dzyubak at debian: /Memory$
*******End Test*******

Summing up.
Even though I have 2GB + 2GB(swap), it looks like my limit is 2900MB.
 From my previous calculation (~ 1.2397 GB), I should be good, right?
Am I missing something?

5) Memory request.
As to me, it looks like the memory request was "1,840,443,761 bytes".
Should be OK, it is not?
The filter itself does not give the details of the "memory allocation 
crash"
so I ran it with valgrind (see below). Looks like there is some memory 
leak, right?


***********Begin Valgring********

dzyubak at debian: /Images$ valgrind 
./itkAnisotropicDiffusionVesselEnhancementImageFilterTest 
H61_8um_100Slices.hdr H61_8um_100Slices_diff_enh_1_1_2.hdr 1 1 2
==15766== Memcheck, a memory error detector.
==15766== Copyright (C) 2002-2006, and GNU GPL'd, by Julian Seward et al.
==15766== Using LibVEX rev 1658, a library for dynamic binary translation.
==15766== Copyright (C) 2004-2006, and GNU GPL'd, by OpenWorks LLP.
==15766== Using valgrind-3.2.1-Debian, a dynamic binary instrumentation 
framework.
==15766== Copyright (C) 2000-2006, and GNU GPL'd, by Julian Seward et al.
==15766== For more details, rerun with: -v
==15766==
Reading input image : H61_8um_100Slices.hdr
==15766== Warning: set address range perms: large range 198880000 
(undefined)
Enhancing vessels.........: H61_8um_100Slices.hdr
==15766== Warning: set address range perms: large range 198880000 
(undefined)
==15766== Warning: set address range perms: large range 198880000 
(undefined)
==15766== Warning: set address range perms: large range 1193280004 
(undefined)
Iteration:      0
**15766** new/new[] failed and should throw an exception, but Valgrind
   cannot throw exceptions and so is aborting instead.  Sorry.
==15766==    at 0x401D5AD: VALGRIND_PRINTF_BACKTRACE (valgrind.h:2366)
==15766==    by 0x401D7F5: operator new[](unsigned) 
(vg_replace_malloc.c:195)
==15766==    by 0x80E2D88: itk::ImportImageContainer<unsigned long, 
itk::SymmetricSecondRankTensor<double, 3> >::AllocateElements(unsigned 
long) const (in 
/mnt/Public/ITK_VTK_Test/Vessel_Enhancement_Diffusion/Images/itkAnisotropicDiffusionVesselEnhancementImageFilterTest)
==15766==    by 0x80C7A7B: itk::ImportImageContainer<unsigned long, 
itk::SymmetricSecondRankTensor<double, 3> >::Reserve(unsigned long) (in 
/mnt/Public/ITK_VTK_Test/Vessel_Enhancement_Diffusion/Images/itkAnisotropicDiffusionVesselEnhancementImageFilterTest)
==15766==    by 0x80C7AF6: 
itk::Image<itk::SymmetricSecondRankTensor<double, 3>, 3>::Allocate() (in 
/mnt/Public/ITK_VTK_Test/Vessel_Enhancement_Diffusion/Images/itkAnisotropicDiffusionVesselEnhancementImageFilterTest)
==15766==    by 0x80C7BF9: 
itk::ImageAdaptor<itk::Image<itk::SymmetricSecondRankTensor<double, 3>, 
3>, itk::NthElementPixelAccessor<float, 
itk::SymmetricSecondRankTensor<double, 3> > >::Allocate() (in 
/mnt/Public/ITK_VTK_Test/Vessel_Enhancement_Diffusion/Images/itkAnisotropicDiffusionVesselEnhancementImageFilterTest)
==15766==    by 0x80F268C: 
itk::HessianRecursiveGaussianImageFilter<itk::Image<double, 3>, 
itk::Image<itk::SymmetricSecondRankTensor<double, 3>, 3> 
 >::GenerateData() (in 
/mnt/Public/ITK_VTK_Test/Vessel_Enhancement_Diffusion/Images/itkAnisotropicDiffusionVesselEnhancementImageFilterTest)
==15766==    by 0x43D5B0E: 
itk::ProcessObject::UpdateOutputData(itk::DataObject*) (in 
/usr/local/lib/InsightToolkit/libITKCommon.so.3.7.0)
==15766==    by 0x438F750: itk::DataObject::UpdateOutputData() (in 
/usr/local/lib/InsightToolkit/libITKCommon.so.3.7.0)
==15766==    by 0x438F673: itk::DataObject::Update() (in 
/usr/local/lib/InsightToolkit/libITKCommon.so.3.7.0)
==15766==    by 0x43D4FDE: itk::ProcessObject::Update() (in 
/usr/local/lib/InsightToolkit/libITKCommon.so.3.7.0)
==15766==    by 0x80EF733: 
itk::AnisotropicDiffusionVesselEnhancementImageFilter<itk::Image<double, 
3>, itk::Image<double, 3> >::UpdateDiffusionTensorImage() (in 
/mnt/Public/ITK_VTK_Test/Vessel_Enhancement_Diffusion/Images/itkAnisotropicDiffusionVesselEnhancementImageFilterTest)
==15766==
==15766== ERROR SUMMARY: 0 errors from 0 contexts (suppressed: 69 from 1)
==15766== malloc/free: in use at exit: 716,721,809 bytes in 14,113 blocks.
==15766== malloc/free: 17,083 allocs, 2,969 frees, 1,840,443,761 bytes 
allocated.
==15766== For counts of detected errors, rerun with: -v
==15766== searching for pointers to 14,113 not-freed blocks.
==15766== checked 518,558,692 bytes.
==15766==
==15766== LEAK SUMMARY:
==15766==    definitely lost: 0 bytes in 0 blocks.
==15766==      possibly lost: 119,782,223 bytes in 10,850 blocks.
==15766==    still reachable: 596,939,586 bytes in 3,263 blocks.
==15766==         suppressed: 0 bytes in 0 blocks.
==15766== Reachable blocks (those to which a pointer was found) are not 
shown.
==15766== To see them, rerun with: --show-reachable=yes
dzyubak at debian: /Images$

*********End Valgrind**********


Luis Ibanez wrote:
>
> Hi Oleksandr,
>
>
> We are glad to hear that you found this Insight Journal paper useful.
>
>
> Just to make the credits straight:
>
>      The orginal filter was proposed in:
>
>        "Vessel enhancing diffusion:
>         A scale space representation of vessel structures."
>         by R. Mannieshing, M.A. Viergever, and W. J . Niessen.
>         Medical Image Analysis, 2006.
>
> The implementation of this filter in ITK code was done by
> Andinet Enquobahrie (at Kitware) and supervised by Stephen Aylward
> (at Kitware).
>
>
> ---------
>
> About your question regarding memory requirements:
>
> 1) The number "6" in the formula comes from the representation
>    of the Hessian matrix in ITK. Hessian matrices are symmetric
>    and therfore, instead of 9 independent components, they only
>    have 6 independent components. Therefore ITK use only 6 doubles
>    for storing them.
>
> 2) Yes, there are more intermediate structures used internally,
>    than the ones used by the Hessian filter.
>
>
> 3) The swap memory should count. That is, you should be able
>    to allocate 4Gb in your machine.
>
>    That's actually an interesting test to perform before we
>    move further.
>
>    Can you check in a simple C++ program that you can allocate
>    an array of 4Gb (well... maybe 3.5Gb) of memory ?
>
>
> 4) When the filter was tested, images of 100x100x100 were used.
>    We will have to profile memory use starting from there...
>
>
> 5) It will be useful to know what the actuall memory request was.
>    Did you got that number as part of the error message ?
>
>    If so, could you please post it to the list ?
>
>
>
>   Thanks
>
>
>      Luis
>
>
>
>
> --------------------------
> Oleksandr Dzyubak wrote:
>> Hi Luis,
>>
>> First of all many thanks all of you for such a good filter, "Vessel 
>> enhancing diffusion filter".
>> With great pleasure I read the article from the the IJ distribution 
>> and the references therein.
>>
>> Since I am working on vessels, of course, I was tempted to give that 
>> filter a try. So I did.
>> As well as Laura, I got the same error message and following your advice
>> and formula, I calculated the memory request.
>>
>> I tested the filter using an image 565x440x100 pixels.
>> BTW, why 6 in your formula "sizeof(double) x 6 bytes per pixel"?
>> Do you store some intermediate results all the time?
>> Lets calculate memory. In my case sizeof(double)=8.
>>
>> octave:2> 8*6*(565*440*100)
>> ans = 1193280000
>>
>> OK. Filter + ImageItself = 1.19 +  0.0497 ~ 1.2397 GB
>>
>> I have 2 GB + 2 GB (swap). As you say, I almost hit the limit but 
>> some piece is still left.
>> Does a swap part count? I cropped the original image (which is 100 
>> times larger then the one I used)
>> down to 47MB just to test the filter and even with such a small image 
>> size the filter fails to allocate memory?
>>
>> Does it mean that this filter has no use for boxes with limited 
>> resources?
>>
>> BTW, the only 
>> "itkAnisotropicDiffusionVesselEnhancementImageFilterTest" fails.
>> The other one, 
>> "itkMultiScaleHessianSmoothed3DToVesselnessMeasureImageFilterTest" 
>> works fine.
>>
>> Just by luck or you implemented another memory model?
>>
>> Thanks,
>>
>> Alex
>>
>> Luis Ibanez wrote:
>>
>>>
>>> Hi Laura,
>>>
>>> This is annoying, but normal.
>>>
>>> This code computes Hessians of images, which in 3D requires
>>> the allocation of sizeof(double) x 6 bytes per pixel.
>>>
>>> That is, you will need 48 bytes per pixel of your image
>>> in order to store the resulting Hessian alone. There will be
>>> of course additional intermediate allocations.
>>>
>>> If you need to process large images you may need a 64bits
>>> machine with a larger memory...
>>>
>>> What is the actual size (in pixels) of the image that
>>> you are processing ?
>>>
>>> Can you process selected regions of the image ?
>>>
>>> Usually there is a lot of empty (or at least, non interesting)
>>> space in medical images. You could use the RegionOfInterest
>>> filter to reduce the vessel enhancing processing to smaller
>>> section of the image.
>>>
>>>
>>> Please let us know,
>>>
>>>
>>>     Thanks
>>>
>>>
>>>        Luis
>>>
>>>
>>>
>>>
>>>
>>> ---------------------------------
>>> Laura Fernandez de Manuel wrote:
>>>
>>>> Hi all,
>>>>  
>>>> We have been checking the implementation of the "Vessel Enhancing 
>>>> Diffusion Filter" depicted here:
>>>>  
>>>> http://insight-journal.org/midas/handle.php?handle=1926/558
>>>>  
>>>> although it works properly with the example 3D images provided 
>>>> (ranging from around 30 to 250 KB) we didn't succeed to make it 
>>>> work in images any larger (5MB images failed already for instance). 
>>>> We work in a system with 4GB RAM so we don't know which can be the 
>>>> source of the "Failed to allocate memory for image" errors that we 
>>>> get. Here, I attach the error message we get:
>>>>  
>>>> ------------------------------------------------------------------------------------------------------ 
>>>>
>>>> ./itkAnisotropicDiffusionVesselEnhancementImageFilterTest.exe 
>>>> image00_2.mhd image_2Enhanced.mhd
>>>> Reading input image : image00_2.mhd
>>>> Enhancing vessels.........: image00_2.mhd
>>>> Iteration:      0
>>>> Computing vesselness for scale with sigma= 0.2
>>>> Exception caught:
>>>> itk::ExceptionObject (0138FB20)
>>>> Location: "class itk::SymmetricSecondRankTensor<double,3> 
>>>> *__thiscall itk::ImportImageContainer<unsigned long,class 
>>>> itk::SymmetricSecondRankTensor<double,3> >:: AllocateElements 
>>>> (unsigned long) const"
>>>> File: itk3.6.0\code\common\itkImportImageContainer.txx
>>>> Line: 193
>>>> Description: Failed to allocate memory for image.
>>>> ------------------------------------------------------------------------------------------------------ 
>>>>
>>>>  
>>>> Thanks a lot!
>>>>  
>>>> carlos & laura
>>>>
>>>>  
>>>>  
>>>>
>>>>
>>>> ------------------------------------------------------------------------ 
>>>>
>>>>
>>>> _______________________________________________
>>>> Insight-users mailing list
>>>> Insight-users at itk.org
>>>> http://www.itk.org/mailman/listinfo/insight-users
>>>
>>> _______________________________________________
>>> Insight-users mailing list
>>> Insight-users at itk.org
>>> http://www.itk.org/mailman/listinfo/insight-users
>>
>>
>>



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