[Insight-users] Re: Sub-volumes registration

[Torsten Rohlfing]

Hi Nic --

Have you considered registering downsampled (potentially smoothed) 
versions of your image stacks? I find it highly unlikely that 6, 9, or 
even 12 degrees of freedom in a rigid (or affine) registration can make 
full use of the type of image resolution that you are talking about. In 
other words -- a rigid registration problem is so highly constrained 
that you should not need anywhere near 2k times 2k times 120 pixels to 
get it "right". (Chances are, it may even be harder to register using 
the full image resolution because the excessively fine image texture may 
create many local minima in the registration cost function).

So my suggestion would be to register, say, downsampled 512x512x120 
stacks and then apply the resulting transformation to the 
full-resolution image(s).

Best,
  Torsten

-- 
Torsten Rohlfing, PhD          SRI International, Neuroscience Program
 Research Scientist             333 Ravenswood Ave, Menlo Park, CA 94025
  Phone: ++1 (650) 859-3379      Fax: ++1 (650) 859-2743
   torsten at synapse.sri.com        http://www.stanford.edu/~rohlfing/

     "Though this be madness, yet there is a method in't"