[Insight-users] Registration & resample problem

[dean.inglis@camris.ca]

The problem I have is to image a small
volume of tissue (~ 1 cm^3) at high
spatial resolution with 3DGRE MRI. 
In such a data set, the (isotropic) 
in-plane resolution is >> than the slice 
thickness. The constituent features within 
the volume of tissue are themselves quite 
small; on average about half the size of 
the in-plane dimension.  To improve the 
overall spatial resolution, I am 
contemplating acquiring an additional data
set, scanned in one of the other two anatomical 
planes (i.e., dat set 1 is axial, data set 2
is coronal or saggital).  My proposal is to 
employ rigid body registration to align the two 
data sets and then resample/interpolate them 
into one data set having increased and isotropic 
spatial resolution. There are other larger
scale anatomical features present in the 
volume that are readily distinguishable, so
the registration phase should not be problematic. 
Does anyone have any suggestions for a
pipeline or some filters that may be
appropriate for the second phase involving 
genaration of the resampled/interpolated/
combined data set?

regards,
Dean