[ITK] Regularizing b-spline deformation in ITKv4

[Nicholas Tustison]

Hi Andriy,

How are you comparing ITKv3 with ITKv4?  I assume you’re running
ITKv3 through BRAINSFit but how are you running ITKv4?

There are a couple of alternative B-spline methods if you’re interested.
There’s B-spline SyN which is described here

http://www.ncbi.nlm.nih.gov/pubmed/24409140 <http://www.ncbi.nlm.nih.gov/pubmed/24409140>

and 

a Demon’s like B-spline algorithm described here

http://www.ncbi.nlm.nih.gov/pubmed/19171516

which both offer different regularization options that are available in
ITKv4.  However, alternative explicit regularization models, such as
thin plate splines, are not available in ITKv4.

Nick





> On May 19, 2015, at 5:38 PM, Andriy Fedorov <fedorov at bwh.harvard.edu> wrote:
> 
> Hi,
> 
> we are in the process of evaluating the possibility of migrating
> workflows from ITKv3 to ITKv4 b-spline based registration (see details
> here [1]).
> 
> One issue that is becoming apparent is that sometime the deformations
> we are getting with ITKv4 lack are a lot more irregular and
> unrealistic than what we used to get in ITKv3 (see case 9 on the page
> referenced).
> 
> At the ITK community hangout last week it was suggested that there are
> some ways in ITKv4 to add regularization to b-spline transformation.
> 
> Is there an example of b-spline regularization we could follow to see
> how this should be done? Is there a significant performance hit if
> this regularization is used?
> 
> Thanks
> 
> AF
> 
> [1] http://www.na-mic.org/Wiki/index.php/BRAINSFit_prostate_registration
> 
> 
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