[ITK] Regularizing b-spline deformation in ITKv4

[Andriy Fedorov]

Hi,

we are in the process of evaluating the possibility of migrating
workflows from ITKv3 to ITKv4 b-spline based registration (see details
here [1]).

One issue that is becoming apparent is that sometime the deformations
we are getting with ITKv4 lack are a lot more irregular and
unrealistic than what we used to get in ITKv3 (see case 9 on the page
referenced).

At the ITK community hangout last week it was suggested that there are
some ways in ITKv4 to add regularization to b-spline transformation.

Is there an example of b-spline regularization we could follow to see
how this should be done? Is there a significant performance hit if
this regularization is used?

Thanks

AF

[1] http://www.na-mic.org/Wiki/index.php/BRAINSFit_prostate_registration


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