# TubeTK/Design Discussions

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## Pre-processing

- Continuous switching anistropic diffusion
- Vessel enhancement filtering (multi-scale) by Frangi

## Object segmentation

- Pixel
- Intensity, multivariate intensity

- Atlas-based
- Register and refine contours

- Region growing / active contours
- Level sets, connected component, ...
- What methods are in Slicer?

## Data structures

## Tube extraction

### Categories

- Pixel-based
- intensity, gradient magnitude, dot product of gradient and the eigenvectors of the hessian, ratios of eigenvalues of the hessian, ...

- Region growing / level-set
- Geodesics
- Connected components
- Active contours

- Tracking / cross-sectional geometry
- Intensity ridge
- Probability ridge
- Match filter

- Atlas / fitting techniques
- VMTK (given endpoints, find lowest-cost path), linear programming,

### Papers

- "A VTK-based, CUDA-optimized Non-Parametric Vessel Detection Method"

## Data structures

- itkTubeSpatialObject

## Topology

- Aylward, MICCAI 2005

## Editing

- Bullitt, IPMI 1997