Hi, Somebody asked during the meeting at UNC if there was a Simplex optimization method in the toolkit It happens that vnl has : vnl_amoeba which seem to be a variant of the Simplex method. it can be found at: Insight/Code/Numerics/vxl/vnl/algo/vnl_amoeba.h This method is wrapped (ITK-Borg-Assimilated) as itkAmoebaOptimizer.h in Insight/Code/Numerics/itkAmoebaOptimizer.h Luis