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<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'>Hello:<o:p></o:p></span></font></p>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'><o:p> </o:p></span></font></p>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'>We received your request to join the mailing list.<o:p></o:p></span></font></p>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'><o:p> </o:p></span></font></p>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'>At the moment, this project is still in its early stages so
we are not ready to accept external developers. <o:p></o:p></span></font></p>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'><o:p> </o:p></span></font></p>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'>We hope to have a version ready for release at the end of
this year.<o:p></o:p></span></font></p>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'><o:p> </o:p></span></font></p>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'>Thank you for your inquiry.<o:p></o:p></span></font></p>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'><o:p> </o:p></span></font></p>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'>I have attached the abstract of the project below for your
information. It is funded by a U.S. Government agency, the National Institutes
of Health.<o:p></o:p></span></font></p>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'><o:p> </o:p></span></font></p>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'>Kevin Cleary<o:p></o:p></span></font></p>
<p class=MsoNormal><font size=2 color=blue face=Arial><span style='font-size:
10.0pt;font-family:Arial;color:blue'> </span></font> <o:p></o:p></p>
<p class=MsoNormal><font size=2 face="Courier New"><span style='font-size:10.0pt;
font-family:"Courier New"'>------------------------------------------------------------------<br>
Kevin Cleary,
Ph.D.
Work phone: 202-687-8253<br>
Associate
Professor
Work fax: 202-784-3479<br>
Deputy Director <br>
<br>
Imaging Science and Information Systems (<st1:place w:st="on">ISIS</st1:place>)
Center<br>
Department of
Radiology
Pager: 202-901-2033<br>
<st1:place w:st="on"><st1:PlaceName w:st="on">Georgetown</st1:PlaceName> <st1:PlaceType
w:st="on">University</st1:PlaceType> <st1:PlaceName w:st="on">Medical</st1:PlaceName>
<st1:PlaceType w:st="on">Center</st1:PlaceType></st1:place>
Cell phone: 202-294-3409<br>
<st1:Street w:st="on"><st1:address w:st="on">2115 Wisconsin Avenue, Suite 603</st1:address></st1:Street>
Home phone: 301-299-0788<br>
<st1:place w:st="on"><st1:City w:st="on">Washington</st1:City>, <st1:State
w:st="on">DC</st1:State>, <st1:PostalCode w:st="on">20007</st1:PostalCode></st1:place>
Home fax: 301-299-0789</span></font><o:p></o:p></p>
<div>
<p class=MsoNormal><font size=3 face="Times New Roman"><span style='font-size:
12.0pt'> <o:p></o:p></span></font></p>
</div>
<p class=MsoNormal><st1:place w:st="on"><font size=2 face="Courier New"><span
style='font-size:10.0pt;font-family:"Courier New"'>ISIS</span></font></st1:place><font
size=2 face="Courier New"><span style='font-size:10.0pt;font-family:"Courier New"'>
center: </span></font><a href="http://www.isis.georgetown.edu/"
title="http://www.isis.georgetown.edu/"><font size=2 face="Courier New"
title="http://www.isis.georgetown.edu/"><span style='font-size:10.0pt;
font-family:"Courier New"'>www.isis.georgetown.edu</span></font></a><br>
<font size=2 face="Courier New"><span style='font-size:10.0pt;font-family:"Courier New"'>Research
group: </span></font><a href="http://www.caimr.georgetown.edu/"
title="http://www.caimr.georgetown.edu/"><font size=2 face="Courier New"
title="http://www.caimr.georgetown.edu/"><span style='font-size:10.0pt;
font-family:"Courier New"'>www.caimr.georgetown.edu</span></font></a><br>
<font size=2 face="Courier New"><span style='font-size:10.0pt;font-family:"Courier New"'>WashCAS:
</span></font><a href="http://www.washcas.org/" title="http://www.washcas.org/"><font
size=2 face="Courier New" title="http://www.washcas.org/"><span
style='font-size:10.0pt;font-family:"Courier New"'>www.washcas.org</span></font></a><br>
<font size=2 face="Courier New"><span style='font-size:10.0pt;font-family:"Courier New"'>Email:
</span></font><a href="mailto:cleary@georgetown.edu"
title="mailto:cleary@georgetown.edu"><font size=2 face="Courier New"
title="mailto:cleary@georgetown.edu"><span style='font-size:10.0pt;font-family:
"Courier New"'>cleary@georgetown.edu</span></font></a><br>
<font size=2 face="Courier New"><span style='font-size:10.0pt;font-family:"Courier New"'>-------------------------------------------------------------------</span></font><o:p></o:p></p>
<p class=MsoNormal><font size=3 face="Times New Roman"><span style='font-size:
12.0pt'><o:p> </o:p></span></font></p>
<p class=ProposalText style='margin-bottom:6.0pt'><font size=2 color=black
face=Arial><span style='font-size:10.0pt'>The goal of this Phase II STTR
proposal is to develop a freely available, open-source software toolkit for
image-guided surgery. This proposal is a partnership between a university-based
biomedical research group (Imaging Science and Information Systems [ISIS]
Center, Department of Radiology, <st1:PlaceName w:st="on">Georgetown</st1:PlaceName>
<st1:PlaceType w:st="on">University</st1:PlaceType>) and a small business
specializing in open-source software development (Kitware, Inc. of <st1:place
w:st="on"><st1:City w:st="on">Clifton Park</st1:City>, <st1:State w:st="on">NY</st1:State></st1:place>).
The partnership of Phase I will be extended to include the Computer-Aided
Diagnosis and Display Laboratory (CADDLab, Department of Radiology, University
of North Carolina) to increase the number and variety of methods in the toolkit
and to evaluate the usability and extensibility of the toolkit by groups beyond
the Phase I development team. <o:p></o:p></span></font></p>
<p class=ProposalText><font size=2 color=black face=Arial><span
style='font-size:10.0pt'>The Image-Guided Surgery Toolkit (IGSTK: pronounced
IGstick) is a high-level component based framework providing common
functionality for image-guided surgery applications. This software framework
will be configurable and based on open-source standards. The framework will
consist of a set of high-level components (2D and 3D viewers, tracker
interfaces, registration modules, etc.) integrated with other lower level
open-source libraries and application programming interfaces (APIs) from
hardware vendors. The toolkit will allow researchers to quickly build prototype
systems for image-guided surgery for specific applications such as minimally
invasive cancer treatments, vascular interventions, and percutaneous spinal
procedures.<o:p></o:p></span></font></p>
<p class=ProposalText><font size=2 color=black face=Arial><span
style='font-size:10.0pt'>The specific aims of the proposal are:<o:p></o:p></span></font></p>
<p class=ProposalText style='mso-margin-top-alt:0in;margin-right:0in;
margin-bottom:6.0pt;margin-left:.5in;text-indent:-.25in;mso-list:l0 level1 lfo1'><![if !supportLists]><font
size=2 color=black face=Arial><span style='font-size:10.0pt'><span
style='mso-list:Ignore'>1.<font size=1 face="Times New Roman"><span
style='font:7.0pt "Times New Roman"'> </span></font></span></span></font><![endif]><b><font
size=2><span style='font-size:10.0pt;font-weight:bold'>Toolkit design</span></font></b><font
size=2><span style='font-size:10.0pt'>. A demonstration framework has been
completed in Phase I. Based on the additional applications proposed here in
Phase II, this framework will be enhanced by re-examining the requirements and
additional components will be designed to provide new functionality. <o:p></o:p></span></font></p>
<p class=ProposalText style='mso-margin-top-alt:0in;margin-right:0in;
margin-bottom:6.0pt;margin-left:.5in;text-indent:-.25in;mso-list:l0 level1 lfo1'><![if !supportLists]><font
size=2 color=black face=Arial><span style='font-size:10.0pt'><span
style='mso-list:Ignore'>2.<font size=1 face="Times New Roman"><span
style='font:7.0pt "Times New Roman"'> </span></font></span></span></font><![endif]><b><font
size=2><span style='font-size:10.0pt;font-weight:bold'>Toolkit implementation
and testing</span></font></b><font size=2><span style='font-size:10.0pt'>. The
additional components defined in Aim 1 will be implemented and documented. A
testing framework will also be developed. A hazard analysis will be performed.<o:p></o:p></span></font></p>
<p class=ProposalText style='mso-margin-top-alt:0in;margin-right:0in;
margin-bottom:6.0pt;margin-left:.5in;text-indent:-.25in;mso-list:l0 level1 lfo1'><![if !supportLists]><font
size=2 color=black face=Arial><span style='font-size:10.0pt'><span
style='mso-list:Ignore'>3.<font size=1 face="Times New Roman"><span
style='font:7.0pt "Times New Roman"'> </span></font></span></span></font><![endif]><b><font
size=2><span style='font-size:10.0pt;font-weight:bold'>Toolkit incorporation
and dissemination</span></font></b><font size=2><span style='font-size:10.0pt'>.
The toolkit will be incorporated in three demonstration clinical applications
involving image guidance: guidewire tracking and display, needle segmentation
and tracking, and liver biopsy. Dissemination activities will be undertaken
with the aim of fostering the use of the toolkit in research and clinical
applications. <o:p></o:p></span></font></p>
<p class=MsoNormal><font size=3 face="Times New Roman"><span style='font-size:
12.0pt'>(end of abstract)<o:p></o:p></span></font></p>
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