[CMake] CMake or Make

[d.1234567890]

I would like to better understand some of the key concepts (best practices) in the use of CMake:

1) Should a typical build process always invoke CMake with the appropriate set of options and then invoke Make
   or rather
use CMake once (as long as the project structure is unchanged) with many different targets for each configuration and then only invoke Make with the appropriate set of targets for the individual build.

2) What would be the best practice to deal with (for example) localized versions of a target? An executable has a common set of objects but (only) differs in the resources that will be bound to the application.

Thank you in advance,
Dieter